More than just a place to enjoy a drink, Dante, a half-demon, uses the Devil May Cry pub as his base of operations from which to carry out his many tasks. Dante carries a large sword and two pistols, which is not surprising considering that most of his missions require him to battle demons.
His clientele are not only numerous but also frequently out of the ordinary; the demon hunter Lady and Trish, who is actually a demon herself, are two prime examples. Young Patty Lowell, who resides in an orphanage and now appears to be the purported sole heir of the powerful and affluent Lowell family, is possibly the most typical company for Dante. Dante is tasked with taking her to the family estate, but things are not going to go as planned.