Inu x Boku SS is a supernatural romantic comedy anime series about Ririchiyo Shirakiin, a sheltered girl who moves into the "Ayakashi Kan" apartment complex. She is accompanied by her Secret Service agent Soushi Miketsukami, who is actually a fox spirit in disguise. As Ririchiyo and Soushi's relationship progresses, they discover secrets about each other and the other residents of Ayakashi Kan. The series follows their adventures as they work together to protect Ririchiyo from harm.